Dragon arrived at the International Space Station on December 8, 2019 and was captured at 2:05 a.m. PDT while flying over 250 statute miles over the South Pacific. The spacecraft was then installed on the Harmony module for the duration of its four-week stay at the orbiting laboratory. Filled with approximately 5,700 pounds of supplies and payloads, Dragon launched aboard a Falcon 9 rocket on December 5, 2019 from Cape Canaveral Air Force Station in Florida.

The Dragon spacecraft that supported the CRS-19 mission previously supported the CRS-4 mission in September 2014 and the CRS-11 mission in June 2017. Dragon is the only spacecraft currently flying that's capable of returning significant amounts of cargo to Earth.