Dragon arrived at the International Space Station on March 9, 2020 and was captured at 3:25 a.m. PDT while flying over 262 statute miles over the Pacific Northwest. The spacecraft was then installed on the Harmony module for the duration of its four-week stay at the orbiting laboratory.

Filled with approximately 4,500 pounds of supplies and payloads, Dragon launched aboard a Falcon 9 rocket on March 6, 2020 from Cape Canaveral Air Force Station in Florida. The Dragon spacecraft that supported the CRS-20 mission previously supported the CRS-10 mission in February 2017 and the CRS-16 mission in December 2018. Dragon is the only spacecraft currently flying that's capable of returning significant amounts of cargo to Earth.